Engineering a Juxtamembrane-Targeting CAR T-Cell Against Mesothelin: A Novel Binder Resilient to Shed Antigen in Ovarian and Pancreatic Cancer
John Scholler, Ai Song, Mansi Deshmukh, Decheng Song, Carl H. June, Don L. Siegel
This paper develops a CAR T-cell targeting the mesothelin stump domain, showing comparable cytotoxicity and effectiveness against resistant tumors compared to standard anti-mesothelin CAR T-cells.
bioRxiv · Aug 2, 2025 · PreprintImmunology