Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome
Ottilie von Loeffelholz, Charles Barchet, Samuel Holvec, Aida Abou Ramadan, Cristina Protuc, Anne Maglott, S. Nimali T. De Silva, Isabelle Hazemann, Bruno P. Klaholz
The paper investigates how the Kozak sequence is recognized during eukaryotic translation initiation using cryo-EM structures, revealing an induced-fit mechanism involving conformational changes in mRNA, rRNA, and initiation factors.
Nature Communications · Jul 8, 2026Peer-reviewedBiochemistry