Suppression of RIPK3 by EZH2 contributes to cigarette smoking-induced chemoresistance in lung cancer
Rong Liu, Aifang Zhang, Jeffrey Yang, Gutian Xiao, Dongshi Chen
This study identifies the EZH2/RIPK3 axis as a mediator of smoking-induced chemoresistance in lung cancer by suppressing RIPK3 expression and impairing ferroptosis.
bioRxiv · Aug 10, 2026 · PreprintCancer Biology