Transcriptional heterogeneity in cancer-associated regulatory T cells is predictive of survival.
Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige Kluz, Gaurav Pandey, Katherine N. Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Jinke Cheng, Song Guo Zheng, , Weizhou Zhang
The paper identifies transcriptional subtypes of tumor-infiltrating regulatory T cells and shows that a CD177+ subset predicts poorer survival in renal clear cell carcinoma and other cancers.
bioRxiv · Nov 26, 2018 · PreprintCancer Biology