Non-blocking modulation as the major mechanism of sodium channel inhibition by riluzole
AK Szabo, K Pesti, P Lukacs, MC Földi, Z Gerevich, B Sperlagh, A Mike
This study shows riluzole inhibits sodium channels primarily through non-blocking modulation rather than direct block, based on experimental and kinetic modeling data.
bioRxiv · Dec 4, 2017 · PreprintPharmacology & Toxicology