Beáta Sperlágh

This study shows that targeting microglial P2Y12 receptor signaling reduces neurodegeneration in Parkinson's disease models using genetic and pharmacological approaches.

This study investigates the role of P2X7 receptors in astrocytic atrophy following status epilepticus in mice, showing that P2X7R antagonism prevents astrocyte damage.

This study identifies microglia as key regulators of cerebral blood flow and neurovascular coupling through P2Y12R-mediated mechanisms in mice and humans.

This study investigates the role of P2Y12R in Parkinson's disease progression in mice, showing that its inhibition can protect against neurodegeneration and neuroinflammation.

The paper identifies specialized somatic microglia-neuron junctions that enable microglia to monitor and protect neuronal function through purinergic signaling.

This study shows riluzole inhibits sodium channels primarily through non-blocking modulation rather than direct block, based on experimental and kinetic modeling data.