A stromal metabolic program suppresses NK-cell immunity to drive tumor progression in HER2-low breast cancer
Kayla Carter, Olajumoke Ogunlusi, Mrinmoy Sarkar, Stephen Akanbi, Christian Nguyen, Manasa Nekkanti, Akash Agarwal, Danielle Fails, Gayan I. Nawaratna, Cory L. Klemashevich, James J. Cai, Devon J. Boland, Tapasree Roy Sarkar
This study identifies a stromal metabolic program in HER2-low breast cancer that suppresses NK-cell immunity, promoting tumor progression through BCAT1-dependent BCKA production.
bioRxiv · Sep 14, 2026 · PreprintCancer Biology