Mrinmoy Sarkar

A stromal metabolic program suppresses NK-cell immunity to drive tumor progression in HER2-low breast cancer

This study identifies a stromal metabolic program in HER2-low breast cancer that suppresses NK-cell immunity, promoting tumor progression through BCAT1-dependent BCKA production.

Spatial immune ecosystems govern therapeutic response in HER2-low breast cancer

This study uses single-cell spatial transcriptomics to show that dendritic cell states and immune architecture in HER2-low breast cancer influence therapeutic response, with specific immune niches linked to resistance or sensitivity.

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.