Role of Immature Choroid Plexus in the Pathology of Autism Spectrum Disorder
Motoi Tanabe, Yuga Saito, Ayaka Takasaki, Keita Nakano, Shunta Yamamoto, Chikako Suzuki, Nao Kawamura, Aki Hattori, Mami Oikawa, Shun Nagashima, Shigeru Yanagi, Tomoyuki Yamaguchi, Toshifumi Fukuda
This study shows that immature choroid plexus in ASD model mice and patient-derived organoids contributes to ASD-like behaviors, and Metformin can restore ChP maturation and social behaviors.
Cell Reports · Dec 27, 2024Peer-reviewedNeuroscience