Author

Tomoyuki Yamaguchi

Tokyo University of Pharmacy and Life SciencesORCID 0000-0002-3070-2885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Aki Hattori· 1 shared Ashley MaynardiD· 1 shared Ayaka Takasaki· 1 shared Barbara TreutleiniD· 1 shared Bruno Gjeta· 1 shared Chikako Suzuki· 1 shared Christoph HarmeliD· 1 shared Cinzia EspositoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Aki Hattori

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2 papers

Recent·Most cited

Integrated cell atlas and tumoroids chart pancreatic cancer therapeutic targets

Quan Xu, Ryo Okuda, Bruno Gjeta, Christoph Harmel, Marina Signer, Matilde Lucioli, Małgorzata Santel, Makiko Seimiya, Cinzia Esposito, Karolina Guja-Jarosz, Ashley Maynard, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Yasuharu Ueno, , J. Gray Camp

The paper integrates single-cell transcriptomes and spatial transcriptomics to identify therapeutic targets in pancreatic cancer by analyzing cell states and ligand-receptor interactions in tumoroids.

bioRxiv · Sep 30, 2025 · PreprintCancer Biology

Role of Immature Choroid Plexus in the Pathology of Autism Spectrum Disorder

Motoi Tanabe, Yuga Saito, Ayaka Takasaki, Keita Nakano, Shunta Yamamoto, Chikako Suzuki, Nao Kawamura, Aki Hattori, Mami Oikawa, Shun Nagashima, Shigeru Yanagi, Tomoyuki Yamaguchi, Toshifumi Fukuda

This study shows that immature choroid plexus in ASD model mice and patient-derived organoids contributes to ASD-like behaviors, and Metformin can restore ChP maturation and social behaviors.

Cell Reports · Dec 27, 2024Peer-reviewedNeuroscience