PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis
Subhransu S. Sahoo, Susmita Gurjar Ramanand, Ileana Cuevas, Yunpeng Gao, Sora Lee, Ahmed Abbas, Xunzhi Zhang, Vinod Kumar, Prasad R. K. Koduru, Sambit Roy, Russell R. Broaddus, Victoria Lin Bae-Jump, Andrew B. Gladden, Jayanthi Sivasothy Lea, Elena Lucas, , Diego H. Castrillón
This study identifies a specific epigenetic mechanism that silences PAX2 to initiate most endometrial cancers.
Journal of Clinical Investigation · Aug 15, 2025Peer-reviewedCancer Biology