Chao Xing

Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Sex-Specific Effects

The paper identifies sex-specific protein responses in human cartilage after ACL injury, showing early remodeling and differences in inflammation, metabolism, and ECM pathways.

A minimally modified AAV9 variant (AAV9fyhr) for enhanced CNS gene delivery by intra-CSF administration.

This paper describes a novel AAV9 variant, AAV9fyhr, that improves CNS gene delivery while minimizing peripheral tissue tropism through targeted amino acid modifications.

GMIP-PLSR: A Nextflow Pipeline for GWAS and Multi-Omics Integration in Gene Prioritization Using PLSR

GMIP-PLSR improves GWAS gene prioritization by integrating multi-omics data using PLSR to address multicollinearity, outperforming PoPS in NAFLD case studies.

EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization

The paper shows EPOP inhibits PRC2.1 by disrupting its dimerization, reducing chromatin association, and preventing over-repression of gene regulators during early differentiation.

Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population

The paper shows that defects in nephron progenitor cell differentiation lead to an expansion of Foxd1+ stromal progenitors in mouse models and identifies a conserved subcluster in human fetal kidneys.

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.

PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis

This study identifies a specific epigenetic mechanism that silences PAX2 to initiate most endometrial cancers.

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity

This study generates a genetically labeled premyelinating oligodendrocyte mouse line to study their morphology, transcriptomics, and role in axon ensheathment and neuronal activity.

The subcommissural organ regulates brain development via secreted peptides

The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.

An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disorders

The paper identifies how reduced ribosome levels in neural progenitor cells contribute to neurodevelopmental disorders and shows that mTOR activation can alleviate these defects.

Delta/ Omicron and Omicron/BA.2 co-infections occurring in Immunocompromised hosts

The paper reports two cases of Delta/Omicron and two cases of Omicron/BA.2 co-infections in immunocompromised hosts detected by genotyping and confirmed by whole genome sequencing.

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

This study shows TP53 promotes neural lineage commitment in hESCs by regulating ciliogenesis and Shh signaling through BBS9.

KDM6B sensitizes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response

This study identifies KDM6B as a key regulator of PARthanatos by modulating MGMT expression and checkpoint response in cancer cells exposed to alkylating agents.

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

The paper identifies CFIm25 as a regulator of MAT2A intron detention and intracellular SAM levels through splicing mechanisms.

STAG2 promotes the myelination transcriptional program in oligodendrocytes

This study shows that STAG2-cohesin promotes myelination by generating promoter-anchored loops at myelination genes in oligodendrocytes, linking cohesin dysfunction to myelination defects in cohesinopathy.

Analyzing Presymptomatic Tissue to Gain Insights into the Molecular and Mechanistic Origins of Late-Onset Degenerative Trinucleotide Repeat Disease

The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.