Author

Jayanthi Sivasothy Lea

The University of Texas Southwestern Medical CenterORCID 0000-0002-8657-4309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Ahmed Abbas· 1 shared Akio Kobayashi· 1 shared Alexandra N. SpirtosiD· 1 shared Andrew B. GladdeniD· 1 shared Ateş Kutay TenekeciiD· 1 shared Chao XingiD· 1 shared Cristel V. CamachoiD· 1 shared Diego H. CastrillóniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Ahmed Abbas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tumor-Intrinsic IFNγ Signaling and Niche Adaptation Drive Early Colonization in Ovarian Cancer Metastasis

Emilija Aleksandrovic, Shaneann R. Fross, Samantha M. Golomb, Wei Ma, Xiyu Liu, Zhuo Zhao, Nikitha M. Das, Tanner C. Reese, Hazel M. Borges, Ateş Kutay Tenekeci, Lei Yu, Jacqueline A. Lopez, Min Zhao, Zhenyu Zhong, Kevin M. Dean, , Siyuan Zhang

This study identifies tumor-intrinsic IFNγ signaling and niche adaptation as key drivers of early colonization in ovarian cancer metastasis using MetTag, a single-cell barcoding approach.

Nature Communications · Sep 3, 2026Peer-reviewedCancer Biology

PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis

Subhransu S. Sahoo, Susmita Gurjar Ramanand, Ileana Cuevas, Yunpeng Gao, Sora Lee, Ahmed Abbas, Xunzhi Zhang, Vinod Kumar, Prasad R. K. Koduru, Sambit Roy, Russell R. Broaddus, Victoria Lin Bae-Jump, Andrew B. Gladden, Jayanthi Sivasothy Lea, Elena Lucas, , Diego H. Castrillón

This study identifies a specific epigenetic mechanism that silences PAX2 to initiate most endometrial cancers.

Journal of Clinical Investigation · Aug 15, 2025Peer-reviewedCancer Biology

RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells

Alexandra N. Spirtos, Marwa W. Aljardali, Sridevi Challa, Sneh Koul, Jayanthi Sivasothy Lea, W. Lee Kraus, Cristel V. Camacho

This study shows that RBN-2397, a PARP7 inhibitor, reduces ovarian cancer cell proliferation and migration, and synergizes with paclitaxel to enhance these effects.

bioRxiv · Aug 20, 2024 · PreprintCancer Biology