TACE reprograms RANKL-mediated differentiation of macrophages by activating the non-canonical pathway of IRF3
Se Hwan Mun, Brian Oh, Shunichi Yokota, Akio Umemoto, Andrew J. Suh, Kyuho Kang, Woojung Kim, David Oliver, Tania Pannellini, Geunho Kwon, Young Yang, Kyung‐Hyun Park‐Min
This study shows TACE regulates osteoclast differentiation by modulating IRF3 and HB-EGF signaling in macrophages during inflammation.
bioRxiv · Feb 14, 2026 · PreprintCell Biology