Membrane-associated shortened Trk receptors promote neuroprotection and robust axon regeneration without ligands
Euido Nishijima, Sari Honda, Yuta Kitamura, Kazuhiko Namekata, Atsuko Kakio Kimura, Xiaoli Guo, Yuriko Azuchi, Chikako Harada, Akira Murakami, Akira Matsuda, Tadashi Nakano, Luis F. Parada, Takayuki Harada
This study introduces a system that forces membrane localization of TrkB's intracellular domain to achieve constitutive activation, enhancing neuroprotection and axon regeneration in glaucoma models.
bioRxiv · May 11, 2022 · PreprintNeuroscience