Luis F. Parada

This study identifies the ARP2/3 complex as a downstream effector of mTORC1 and mTORC2 hyperactivation in PTEN-deficient neural cells, showing its inhibition can rescue disease phenotypes.

This study introduces a system that forces membrane localization of TrkB's intracellular domain to achieve constitutive activation, enhancing neuroprotection and axon regeneration in glaucoma models.

This paper describes a method to generate clonal male and female mice using CRISPR/Cas9 to delete the Y chromosome in embryonic stem cells, enabling tetraploid complementation to produce viable mice.

This study uses single-cell RNA sequencing to analyze SVZ stem cells across aging in mice, identifying distinct cell types and aging-related changes in stem cell behavior.