Insulin Growth Factor 1 affects glutamate receptor activity differently in primary cultures of neocortical versus hippocampal neurons
Urooj Fatima, Akshay Padala, Steven W. Barger
This study shows IGF-1 enhances glutamate responses in hippocampal neurons but inhibits them in neocortical neurons via AMPA receptor suppression, suggesting neuroprotective roles in the neocortex.
bioRxiv · Apr 7, 2026 · PreprintNeuroscience