Formulation, Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Glibenclamide for Bioavailability Enhancement in Wistar Rats
Khalid Bashir Mir, Nisar Ahmed Khan, Mehraj D. Shah, Alamgir A. Dar
This study improves the oral bioavailability of Glibenclamide by formulating amorphous solid dispersions with Poloxamer-188, showing enhanced dissolution and pharmacokinetic performance in Wistar rats.
bioRxiv · Jan 31, 2024 · PreprintBiochemistry