A transcriptional mechanism involving R-loop, m6A modification and RNA abasic sites regulates an enhancer RNA of APOE.
Jason A. Watts, Christopher Grunseich, Yesenia Rodriguez, Yaojuan Liu, Dongjun Li, Joshua T. Burdick, Alan Bruzel, Robert J. Crouch, Robert W. Mahley, Samuel H. Wilson, Vivian G. Cheung
The paper identifies an enhancer RNA, AANCR, regulated by R-loops, m6A modification, and RNA abasic sites that influences APOE expression and Alzheimer's disease susceptibility.
bioRxiv · May 1, 2022 · PreprintMolecular Biology