Vivian G. Cheung

Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

The paper identifies guanine quadruplexes as mediators of mitochondrial RNA polymerase pausing and shows their impact on mitochondrial transcription and function.

Allele-specific silencing of a dominant SETX mutation in familial amyotrophic lateral sclerosis type 4

The paper demonstrates that allele-specific siRNA can effectively silence a dominant SETX mutation in ALS4, restoring R-loop levels in patient cells.

A transcriptional mechanism involving R-loop, m6A modification and RNA abasic sites regulates an enhancer RNA of APOE.

The paper identifies an enhancer RNA, AANCR, regulated by R-loops, m6A modification, and RNA abasic sites that influences APOE expression and Alzheimer's disease susceptibility.