Gap scheduling of a PARP inhibitor and nanoparticle TOP1 agent combination avoids synergistic bone marrow toxicity
Lenka Oplustil O’Connor, Anderson T. Wang, Claire Sadler, Jennifer Barnes, Rajesh Odedra, Aaron Smith, Gareth Hughes, Alan Lau, Andres Tellez, Scott D. Eliasof, Elaine B. Cadogan, Mark J. O’Connor
The paper identifies a gap schedule for combining a PARP inhibitor and a tumor-targeted nanoparticle chemotherapy to enhance efficacy while reducing bone marrow toxicity.
bioRxiv · Apr 30, 2025 · PreprintCancer Biology