Novel Biosensor Identifies Ruxolitinib as a Potent and Cardioprotective CaMKII Inhibitor
Oscar E. Reyes Gaido, Jonathan M. Granger, Lubika J. Nkashama, Brian Leei Lin, Alan Long, Olurotimi O. Mesubi, Kate L. Schole, Chantelle E. Terrillion, Jun O. Liu, Elizabeth D. Luczak, Mark E. Anderson
The paper develops a CaMKII biosensor for high-throughput screening and identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor effective in preventing atrial fibrillation.
bioRxiv · Sep 24, 2022 · PreprintMolecular Biology