Alato Okuno

Probiotic lactic acid bacteria induce regulatory functions in γδ T cells

This study shows that probiotic lactic acid bacteria induce regulatory γδ T cells that reduce IL-8 production in intestinal epithelial cells.

Lactococcus lactis subsp. cremoris C60 creates a type I regulatory T cell-dominant anti-inflammatory intestinal environment through functional modification of dendritic cells

This study shows that Lactococcus lactis subsp. cremoris C60 increases IL-10-producing Tr1 cells in the intestine, reducing inflammation in DSS-induced colitis.

Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin A production from B cells through functional modification of dendritic cells in intestinal environment

This study identifies Lactococcus lactis subsp. cremoris C60 as a probiotic strain that enhances IgA production via DC-mediated signaling in mice and humans.