Epigenetic dysregulation of Th2 cytokine genes in MuSK myasthenia gravis and its modulation by immunosuppressive therapy
Cansu Elmas Tunc, Andrea Stoccoro, Martina Lari, Farzin Salehi, Veronica Iovino, Alba Cepele, Jennifer Huber, Francisca Faber, Marlene Wolfsgruber, Omar Keritam, Rosa Weng, Anja Steinmaurer, Theresa Koenig, Melania Guida, Hakan Çetin, , Inga Koneczny
This study examines DNA methylation of Th2 cytokine genes in MuSK myasthenia gravis and finds hypomethylation of IL4 and IL13 promoters associated with increased cytokine expression, suggesting epigenetic dysregulation influenced by immunosuppressive therapy.
bioRxiv · Aug 11, 2026 · PreprintImmunology