ALS sensitive spinal motor neurons enter a degenerative downward spiral of impaired splicing and proteostasis
Dylan E. Iannitelli, Albert Tan, Emma Nguyen, Asha Babu, Setiembre Delfina Elorza, Tyler Joseph, Sophie Zaaijer, Disi An, Michael Emmerson Ward, Esteban O. Mazzoni
This study identifies differences in proteostasis and splicing between ALS-resistant cranial motor neurons and ALS-sensitive spinal motor neurons derived from iPSCs.
bioRxiv · Mar 26, 2022 · PreprintNeuroscience