Esteban O. Mazzoni

This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.

This study shows that CTCF-ZF1 RNA interactions are essential for maintaining cell-type-specific chromatin loops during differentiation, with disruption leading to gene dysregulation and loop loss.

The paper identifies zinc finger proteins that establish distinct chromatin boundaries at Hox clusters during development, working with cohesin to regulate cell fate.

The paper identifies molecular signatures of proteostasis differences between ALS-resistant and -sensitive motor neurons using transcriptome and proteome analysis.

Capybara measures cell identity and fate transitions using a continuum-based approach, showing improved performance in annotating cells and identifying transitions in hematopoiesis and reprogramming.

This study identifies differences in proteostasis and splicing between ALS-resistant cranial motor neurons and ALS-sensitive spinal motor neurons derived from iPSCs.

The paper shows that PRC1 maintains neuronal subtype identity independently of PRC2, by preserving chromatin topology and transcriptional memory during differentiation.

The paper uses synthetic genomic reconstitution to study Hox cluster regulation, finding that distal enhancers are required for full transcriptional output while chromatin remodeling can occur without them.

The paper develops Bichrom, a bimodal neural network that models sequence and preexisting chromatin data to predict TF-DNA binding and shows preexisting chromatin improves binding specificity prediction for some TFs.

A CRISPR screen identifies ZBTB11 and ZFP131 as factors maintaining pluripotency by pausing POL II at pro-differentiation genes.

This paper develops a proteomics method to quantify protein abundances from as few as 1,000 mammalian cells with high reproducibility and accuracy.

The paper investigates how posterior HOX TFs differ in their ability to bind inaccessible chromatin, leading to distinct gene expression patterns during motor neuron differentiation.

The paper identifies proteostatic differences between ALS-resistant and sensitive motor neurons using stem cell-derived models.

The paper describes a pipeline for de novo assembly, delivery, and expression of a 101 kb human gene in mouse cells, demonstrating functional evaluation of a full-length gene.

The paper introduces SeqUnwinder, a method to identify sequence features specific to overlapping regulatory annotations, demonstrating its application on TF binding and chromatin state data.