Two-photon volumetric study of cleared, invasive ductal carcinoma breast tissue samples and associated axillary lymph nodes
Uma Pisarović, Loes F. S. Kooreman, Thiemo J. A. van Nijnatten, Albert V. Bitorina, Sven Hildebrand, Anna Schueth
This study uses two-photon microscopy with MASH clearing to image 3D structures of invasive ductal carcinoma breast tissue and axillary lymph nodes, revealing ECM remodeling in early-stage tumors.
bioRxiv · Nov 7, 2025 · PreprintCancer Biology