A bioorthogonal antibody-based chemically-induced-dimerization switch for therapeutic application
Alexander J. Martinko, Hai L. Tran, Erin F. Simonds, Allison L. Cooke, Zhong Xian Huang, Sruthi Raguveer, Judit Pina Agullet, Suchitra Prasad, Catherine C. Going, Lisa A. Marshall, Timothy Park, Sunandan Banerjee, Ramsay Macdonald, Mike Jian, Kenneth Ng, , Zachary B. Hill
The paper introduces a CID system using humanized antibodies and a clinically approved drug for controlled therapeutic applications.
bioRxiv · Apr 11, 2023 · PreprintSynthetic Biology