Sustained epigenetic rejuvenation of serially engrafting human iPSC-derived HSCs
Arjun Jain, Jacky Li, Xiaojie Yu, Adeleye Opejin, Darren Yu, Anastasia Vavilina, Alexandre Trapp, Jared Tumiel, Zachary Chiang, Esequiel Pastrana, Caroline Polanco, Jorge Pachas, Miguel Pulido, Bianca Carapia, Fredrick Lopez, , Anastasia V. Shindyapina
This study shows that iPSC-derived HSCs can maintain youthful epigenetic features through serial transplantation and differentiation.
bioRxiv · Jul 17, 2026 · PreprintCell Biology