Zachary Chiang

This study shows that iPSC-derived HSCs can maintain youthful epigenetic features through serial transplantation and differentiation.

This paper introduces UTMM, a method to simultaneously measure transcriptomes and mechanical properties in intact embryos, revealing coupling between RNA expression and intracellular compliance during early development.

The paper introduces ExIGS, a method linking nuclear abnormalities to chromatin repression hotspots in progeria fibroblasts.

AtacWorks denoises and identifies accessible chromatin regions from low-quality ATAC-seq data, achieving high-resolution results with minimal input.

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.