Alexandre Trapp

This study shows that iPSC-derived HSCs can maintain youthful epigenetic features through serial transplantation and differentiation.

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

This study introduces scAge, a probabilistic method to estimate epigenetic age in single cells, validated in mice, showing cell-level aging heterogeneity and rejuvenation events.

This paper develops a cost-effective method for epigenetic age profiling using shallow methylation sequencing data, demonstrating its application in mouse blood samples and identifying effects of calorie restriction and cellular reprogramming on aging.

The paper introduces TIME-Seq, a low-cost method for epigenetic age prediction, and validates it on mouse and human samples, showing improved scalability and accuracy.

The paper identifies a unique myeloid progenitor cell type, TC90, specific to neonatal naked mole-rats that supports innate immunity during early development.

The paper uses epigenetic clocks to show rejuvenation during early mouse and human embryogenesis followed by aging.