Author

Anastasia V. Shindyapina

Brigham and Women's HospitalORCID 0000-0002-7336-3086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Developmental Biology· 1 Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Vadim N. GladysheviD· 4 shared Alexander TyshkovskiyiD· 2 shared Alexandre TrappiD· 2 shared Jesse R. PoganikiD· 2 shared José Pedro CastroiD· 2 shared Steve HorvathiD· 2 shared Adeleye OpejiniD· 1 shared Alaattin KayaiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersSystems Biology

Vadim N. GladyshevORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sustained epigenetic rejuvenation of serially engrafting human iPSC-derived HSCs

Arjun Jain, Jacky Li, Xiaojie Yu, Adeleye Opejin, Darren Yu, Anastasia Vavilina, Alexandre Trapp, Jared Tumiel, Zachary Chiang, Esequiel Pastrana, Caroline Polanco, Jorge Pachas, Miguel Pulido, Bianca Carapia, Fredrick Lopez, , Anastasia V. Shindyapina

This study shows that iPSC-derived HSCs can maintain youthful epigenetic features through serial transplantation and differentiation.

bioRxiv · Jul 17, 2026 · PreprintCell Biology

Molecular signatures of longevity identify compounds that extendmouse lifespan and healthspan

Anastasia V. Shindyapina, Alexander Tyshkovskiy, Perinur Bozaykut, José Pedro Castro, Maxim V. Gerashchenko, Alexandre Trapp, Margarita V. Meer, Bohan Zhang, Jesse R. Poganik, Steve Horvath, Richard A. Miller, Vadim N. Gladyshev

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

bioRxiv · Jun 26, 2025 · PreprintSystems Biology

A single cell atlas of the mouse seminal vesicle

Fengyun Sun, Kathleen Desevin, Yu Fu, Shanmathi Parameswaran, Jemma Mayall, Vera D. Rinaldi, Nils Krietenstein, Artür Manukyan, Qiangzong Yin, Carolina Galan, Chih-Hsiang Yang, Anastasia V. Shindyapina, Vadim N. Gladyshev, Manuel G. Garber, John Even Schjenken, Oliver J. Rando

This study creates a single-cell RNA-seq atlas of the mouse seminal vesicle, identifying secretory and immune cell populations and their transcriptomes.

G3 Genes Genomes Genetics · Feb 28, 2025Peer-reviewedGenomics

Rapamycin treatment during development extends lifespan and healthspan

Anastasia V. Shindyapina, Yongmin Cho, Alaattin Kaya, Alexander Tyshkovskiy, José Pedro Castro, Juozas Gordevičius, Jesse R. Poganik, Steve Horvath, Leonid Peshkin, Vadim N. Gladyshev

Rapamycin treatment during early life extends lifespan and healthspan in mice and Daphnia magna by slowing development and delaying aging.

bioRxiv · Feb 18, 2022 · PreprintDevelopmental Biology

Germline burden of rare damaging variants negatively affects human healthspan and lifespan

Anastasia V. Shindyapina, Aleksandr Zenin, Andrei E. Tarkhov, Didac Santesmasses, Peter O. Fedichev, Vadim N. Gladyshev

This study shows that the burden of rare protein-truncating variants negatively impacts human healthspan and lifespan in large cohorts.

eLife · Apr 6, 2020Peer-reviewedGenetics