Cognitive function depends upon Satb2 gene dosage in cortical projection neurons
Thomas S. Finn, Jeremiah Tsyporin, Min Dai, Sherry Jingjing Wu, Gabrielle Isabelle F. Servito, Xiaokuang Ma, John Zhang, Esther Park, Charlene Guo, Austin Shubert, Hailey Lizarraga, Ariella Angelini Stewart, Vipin Kumar, Giovanni J. Marrero, Yufei Si, , Bin Chen
This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.
bioRxiv · Jun 16, 2026 · PreprintNeuroscience