Giovanni J. Marrero

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.

This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.

The paper identifies Kat8 and the NSL complex as essential for lung epithelial repair and maps transcription factor dependencies in alveolar repair trajectories using SAGE.

This paper introduces an imaging-free spatial transcriptomics method using molecular diffusion patterns and UMAP to reconstruct spatial data with high fidelity and scalability.

The paper shows pyramidal neurons influence the survival and identity of specific interneuron subtypes through non-synaptic mechanisms.

Slide-tags enables spatial localization of single nuclei for multi-modal spatial genomics, achieving high-resolution mapping and multiomic profiling in various tissues.

The paper identifies cell-type specific circuits formed by subtypes of somatostatin interneurons in the cortex through genetic targeting and connectivity analysis.