Pervasive Induction of Regulatory Mutation Microclones in Sun-exposed Skin
Vijay Menon, Alejandro García-Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg A. Palmatier, Christine J. Ko, Kenneth Yee Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash
The paper reports that sun exposure induces pervasive mutations at UV-sensitive RNA-processing gene promoters, with clonal expansion observed in both tumor suppressor gene hotspots and CPD hyperhotspots.
bioRxiv · Sep 12, 2024 · PreprintGenomics