Christine J. Ko

This study uses single-cell and spatial sequencing to identify interferon-driven pathways and retroelement expression in cutaneous lupus, showing their association with disease pathology.

This study shows that inhibiting SRSF3 promotes epidermal differentiation and reduces cSCC risk, supported by clinical data on existing inhibitors.

The paper reports that sun exposure induces pervasive mutations at UV-sensitive RNA-processing gene promoters, with clonal expansion observed in both tumor suppressor gene hotspots and CPD hyperhotspots.