Mio Nakamura

This study compares dermatomyositis and lupus skin lesions using single-cell RNA-sequencing to identify inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

The paper reports that sun exposure induces pervasive mutations at UV-sensitive RNA-processing gene promoters, with clonal expansion observed in both tumor suppressor gene hotspots and CPD hyperhotspots.

This study examines the effects of secukinumab on transcriptomic changes in psoriatic skin and T cell subsets over 12 weeks, showing significant reduction in IL17A and related genes.