Open-source mapping and variant calling for large-scale NGS data from original base-quality scores
Olga A. Krasheninina, Yih-Chii Hwang, Xiaodong Bai, Aleksandra Zalcman, Evan K. Maxwell, Jeffrey G. Reid, William J. Salerno
The paper defines an open-source, lossless read-mapping protocol for NGS data and demonstrates direct variant calling without base quality score recalibration.
bioRxiv · Dec 15, 2020 · PreprintBioinformatics