Cell cycle dysregulation contributes to neurodegeneration in humanneurons from ALS/FTD-related C9orf72 repeat expansion carriers.
SK Imran Ali, Ling Lian, Hayley Robinson, Noah J. Daniels, Aleph Prieto, Gunnar H.D. Poplawski, Rodrigo Lopez-Gonzalez
This study identifies cell cycle dysregulation as a therapeutic target in C9orf72 ALS/FTD using iPSC-derived neurons and shows that CDK4/6 inhibition rescues neuronal survival.
bioRxiv · Jun 4, 2025 · PreprintNeuroscience