Rodrigo Lopez-Gonzalez

This study identifies cell cycle dysregulation as a therapeutic target in C9orf72 ALS/FTD using iPSC-derived neurons and shows that CDK4/6 inhibition rescues neuronal survival.

This study uses patient-derived cerebral organoids to show that MOPD I mutations cause disrupted mitotic spindle orientation, leading to premature neurogenesis and cortical layering defects.

The paper shows that ALS genes FUS, TAF15, and MATR3 regulate the MHC II antigen presentation pathway by downregulating HLA-DR and CD74 through loss of CIITA, with implications for immune system failure in ALS.