LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motif
Md. Shariful Islam, Valentín Cóppola-Segovia, Alessandra Musso, Darren J. Moore
This paper investigates how LRRK2 phosphorylates ArfGAP1, affecting its localization, activity, and toxicity in neurons, with implications for Parkinson's disease.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience