Self-Supervised Missing Wedge Correction in Soft X-Ray Tomography: Towards Accurate Cellular Morphology and Volume Quantification
ShaoSen Chueh, Mary Lopez-Perez, Charlotte de Ceuninck van Capelle, Takashi Ishikawa, Alessandro Zannotti, Victoria A. Castro, Gema Calvo, Pablo Gastaminza, Conal Mcintyre, David Rogers, Stephen J. M. O'Connor, Martina Donnellan, Jeremy C. Simpson, Sergey Kapishnikov
This paper introduces a self-supervised model to correct missing wedge artifacts in soft X-ray tomography, improving volume quantification and morphology accuracy in cellular structures.
bioRxiv · Dec 25, 2025 · PreprintCell Biology