Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids
Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, Vivekananda Sarangi, Alexej S. Abyzov, Andre Levchenko, Flora Maria Vaccarino
This study uses morphogen gradients in organoids to generate human brain neuronal lineages and identifies interindividual variability in response to these signals.
bioRxiv · May 18, 2024 · PreprintNeuroscience