Andre Levchenko

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

This study identifies SPINK1 as a regulator of epigenomic states and stemness in PDAC through its interaction with COL18A1 and endostatin release.

The paper applies a Neyman-Pearson framework to single-cell TNF-NF-κB signaling data to quantify decision-making performance and detect pathway failures.

The paper identifies phenotype-specific signaling networks in glioblastoma cells, showing that invasive spread is linked to DNA damage response and AKT-mTOR activation, with 14-3-3 proteins mediating phosphorylation and predictive phospho-site signatures for patient survival.

The paper investigates how Ca2+ oscillations are decoded by the ERK cascade in pancreatic β-cells using fluorescent biosensors and reveals sequential signal processing along the pathway.

The paper shows how VEGF signaling coordinates multiple phenotypes through oscillations in the Src-TEM4-YAP pathway with feedback regulation.

This study identifies YAP's role in controlling cell migration and invasion via a Rho-GTPase switch, with implications for glioblastoma progression.

This study investigates the role of cytokine and FGF2 signaling in inducing entosis and vasculogenic mimicry in glioblastoma, linking macrophage activity to alternative vascularization mechanisms.

This study examines how glucose-induced calcium oscillations in MIN6 cells can be modulated by PIP2 levels and cell-cell communication through optogenetics and calcium imaging.

This study uses morphogen gradients in organoids to generate human brain neuronal lineages and identifies interindividual variability in response to these signals.

The paper investigates spatial and temporal patterns of Tip/Stalk specification during angiogenesis using a controlled model and mathematical analysis, revealing an order-disorder transition in NOTCH signaling.

The paper identifies cell-to-cell communication between mesothelial cells and alveolar tuft cells that regulates lung regeneration after pneumonectomy.

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

The paper models and computes decision making errors in a molecular signaling system with two outputs using single cell measurements of NFκB and ATF-2 concentrations.

The paper analyzes single-cell RNA sequencing data from early SARS-CoV-2 infection in a humanized model to show how the virus exploits tissue repair mechanisms in airway epithelial cells.

The paper identifies a molecular clock mechanism that regulates cell migration in confined spaces through cyclic RhoA activity driven by Ca2+ and GEF-H1 oscillations.

Connectome quantifies and visualizes cell-cell signaling networks from single-cell RNA-sequencing data using a software package for R.

The paper shows that PKA-R translocation to the plasma membrane can both enhance and inhibit kinase activity depending on concentration, affecting cell migration directionality.

This paper introduces decision-theoretic and statistical methods to model signaling outcomes in cells, using single-cell data to analyze decision accuracy and dynamics in biological systems.

The paper shows that pericytes enhance angiogenesis under high TNF doses, with a mathematical model explaining the switch from pro- to anti-angiogenic effects of TNF.

The paper shows quorum sensing in bacteria can detect environmental changes and uses a new signaling mechanism involving protein synthesis and dilution rates to process dynamic inputs.

The paper shows that cell-cell communication improves the ability of cell groups to detect weak chemical gradients, but this benefit is limited by signaling noise.