Author

Alex Nemiroff

Praxis Precision Medicines Inc. (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ben RolloiD· 2 shared Christopher A. ReidiD· 2 shared Kelley Dalby· 2 shared Linghan Jia· 2 shared Snezana MaljeviciD· 2 shared Steven PetrouiD· 2 shared Svenja PacherneggiD· 2 shared Alicia Sedó· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Ben RolloORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Distinctive in vitro phenotypes in iPSC-derived neurons from patients with gain- and loss-of-function SCN2A developmental and epileptic encephalopathy

Miaomiao Mao, Cristiana Mattei, Ben Rollo, Sean Byars, Claire Cuddy, Géza Berecki, Jacqueline Heighway, Svenja Pachernegg, Trevelyan R. Menheniott, Danielle Apted, Linghan Jia, Kelley Dalby, Alex Nemiroff, Saul Alator Mullen, Christopher A. Reid, , Steven Petrou

This study compares iPSC-derived neurons from patients with gain- and loss-of-function SCN2A variants, finding distinct electrophysiological and transcriptomic changes associated with different disease presentations.

bioRxiv · Feb 14, 2023 · PreprintNeuroscience

Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsy

Melody Li, Nikola Jancovski, Paymaan Jafar‐Nejad, Lisseth Estefania Burbano, Ben Rollo, Kay Richards, Lisa Drew, Alicia Sedó, Svenja Pachernegg, Armand Soriano, Linghan Jia, Todd Blackburn, Blaine Russell Roberts, Alex Nemiroff, Kelley Dalby, , Steven Petrou

This study shows that reducing SCN2A function with an antisense oligonucleotide improves survival and behavior in a mouse model of early seizure onset DEE.

bioRxiv · Sep 9, 2020 · PreprintNeuroscience