Functional brain age prediction suggests accelerated aging in preclinical familial Alzheimer's disease, irrespective of fibrillar amyloid-beta pathology
Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian Andrew Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Rhys Farlow, Serge G. Gauthier, Tammie L.S. Benzinger, John C. Morris, Randall John Bateman, John C.S. Breitner, , The Dominantly Inherited Alzheimer Network (DIAN)
The paper develops a model to predict brain aging from resting state fMRI and finds accelerated brain aging in preclinical Alzheimer's disease, independent of amyloid-beta pathology.
bioRxiv · May 6, 2020 · PreprintNeuroscience