Alexa Pichet Binette

The paper compares three plasma proteomic metrics across organ systems to assess their associations with brain structure and neurodegenerative disease, finding distinct relationships and modest predictive value.

The paper identifies robust multicellular axes associated with Alzheimer's disease pathology and sex using single-cell data from 427 donors, validated in an independent dataset.

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.

The paper examines how aging, Alzheimer's pathology, and APOE4 genotype affect longitudinal functional connectivity and episodic memory in older adults.

The paper examines how precuneus activity during memory retrieval relates to future amyloid burden and cognitive outcomes in APOE4 carriers and non-carriers.

The paper compares medial temporal lobe atrophy patterns in early-onset and late-onset amnestic Alzheimer's disease, finding similar atrophy levels but differences in specific subregions.

This study assesses white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease by analyzing signal measures from different MRI contrasts and their associations with clinical variables.

This study finds that higher cholesterol and diastolic blood pressure levels are linked to reduced brain functional connectivity over time in individuals at risk for Alzheimer's disease.

The paper examines associations between white matter microstructure and Aβ/tau pathology in specific brain bundles in at-risk older adults, finding diffusion metrics linked to Aβ and tau levels at cortical endpoints.

The paper develops a model to predict brain aging from resting state fMRI and finds accelerated brain aging in preclinical Alzheimer's disease, independent of amyloid-beta pathology.

The paper identifies distinct morphometric network changes in aging and Alzheimer’s disease, showing additive effects of aging and AD on GM loss, with unique whole-brain pattern variability in AD.