Optical control of sphingolipid biosynthesis using photoswitchable sphingosines
Matthijs A. Kol, Alexander J.E. Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M. Korneev, Dirk H. Trauner, Joost C. M. Holthuis
This study introduces light-sensitive sphingosines (caSphs) that allow reversible control of sphingolipid biosynthesis through photo-isomerization, enabling precise manipulation of lipid production in living cells.
Journal of Lipid Research · Dec 11, 2024Peer-reviewedBiochemistry