Dirk H. Trauner

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

This study evaluates photopharmacology agents in human and mouse brain tissue to control epilepsy, finding that caged propofol suppresses epileptiform activity across species.

The paper develops a photoswitchable antagonist for the dopamine D1 receptor to enable precise temporal and spatial control of receptor activity in the brain.

This study identifies spindle-localized F-actin as critical for organizing polar MTOCs and ensuring accurate meiotic spindle formation and chromosome segregation in mammalian oocytes.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This paper introduces a photoswitchable opioid agonist that enables optical control of peripheral analgesia with reduced side effects.

This study introduces light-sensitive sphingosines (caSphs) that allow reversible control of sphingolipid biosynthesis through photo-isomerization, enabling precise manipulation of lipid production in living cells.

This study introduces AB2, a photochromic ligand that modulates cardiac electrophysiology via light, converting ventricular arrhythmias into sinus rhythm in an ex-vivo heart model.

This paper introduces PHOTACs, a method to optically degrade specific proteins in brain tissue, and demonstrates its effectiveness in reducing synaptic function in mice.

This study shows that somatic nicotinic acetylcholine receptors in VTA dopamine neurons modulate firing properties and reward-related behaviors through optical manipulation.