QTL analysis of macrophages from an AKR/JxDBA/2J intercross identified the Gpnmb gene as a modifier of lysosome function
Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski, Alexander M. Alzayed, Sophia DeGeorgia, Eve Schodowski, C. Alicia Traughber, Jonathan D. Smith
This study identifies Gpnmb as a modifier of lysosome function in macrophages using QTL analysis in an AKR/JxDBA/2J intercross, showing its impact on proteolysis but not cholesterol metabolism.
Scientific Reports · May 13, 2021Peer-reviewedGenetics